For over 2,000 years, Reishi extract has been used as a "cure-all" herbal remedy in Chinese Medicine, with the oldest written record of any medicinal mushroom in Shen Nong's Herbal Classic. Although it may not be totally accurate to claim that Reishi extract cures everything, traditional as well as modern use indicates that it may be a powerful anti-inflammatory agent in a large host of conditions, including arthritis.
Reishi frequently gets prescribed in Traditional Chinese Medicine for its analgesic, anti-inflammatory and anti-arthritic effects. Much recent research appears to validate this traditional use, as the majority of studies have yielded positive results. While looking through published articles on Reishi and arthritis, I found only two studies that showed inconclusive results, both of which were conducted by the same team of researchers. (1,2)
A U.S. based study conducted in 1993 showed that a water extract of Ganoderma lucidum (Reishi) exhibited "significant anti-inflammatory activity." (4) Ten years later, an Indian research paper was published which stated that the use of Reishi extract helped decrease inflammation in acute edema by 56% and in chronic edema by 60%. (3) Using the "Article References" link on this page, you will find references to seven additional research articles that confirm Reishi extract as a powerful anti-inflammatory agent. (5,6,7,8,9,10,11)
Next we'll be looking at some studies that more directly relate to the use of Reishi extract with arthritis. A paper published in 2006 by Blum et al. claimed to provide supporting clinical evidence demonstrating that use of Reishi extract for joint health was both safe and effective. (12)
Also that same year, a Chinese study by Xi Bao et al. came to the conclusion that Reishi plus another medicinal herbal remedy commonly used in China seemed to have a "beneficial immunomodulatory effect" on arthritis. (13)
The answer as to how, precisely, Reishi extract accomplishes this "immunomodulatory effect" may have been given by another Chinese study the following year, which states that an isolated Reishi polysaccharide peptide "significantly inhibited" RASF, which is an indicator of rheumatoid arthritis. (RASF stands for "Rheumatoid Arthritis Synovial Fibroblasts.") (14)
Several additional papers have been published that summarize positive results in the use of Reishi against arthritis. (15,16,17) One even states that Reishi compares favorably to prednisone, albeit without side effects. (18) On the other hand, a separate study found that supplementing with Reishi helped balance the side effects of prednisolone* that were experienced by some patients, including protein in the urine and cell toxicity. (19) (Prednisolone is the active compound of prednisone, which gets broken down by the liver and converted to prednisolone.)
In conclusion, the majority of research on the use of Reishi extract for inflammation or arthritis appears to support its effectiveness. Please remember that it is very important to always consult a licensed medical doctor before using any herb for medicinal purposes.
Name clarification: The Japanese name Reishi includes many closely related species. By far the most prevalent is Ganoderma lucidum (Common Reishi or Red Reishi), a species rare in the U.S. but common in South East Asia. The English common name for Ganoderma lucidum is Varnished Conk. In China, its known as Ling Zhi.
Several closely related species of Ganoderma also go by the name of "Reishi". Most common of these are the Hemlock Reishi (Ganoderma tsugae) found on Hemlocks in the Appalachian Mountains, and the Chinese species "Black Reishi" (Ganoderma sinense). Less common are Ganoderma resinaceum (sometimes called "Red Reishi," although that name is more often used for G. lucidum), Ganoderma neo-japonicum (no common name other than "Reishi"), and Ganoderma japonicum (Purple Reishi).
Reishi frequently gets prescribed in Traditional Chinese Medicine for its analgesic, anti-inflammatory and anti-arthritic effects. Much recent research appears to validate this traditional use, as the majority of studies have yielded positive results. While looking through published articles on Reishi and arthritis, I found only two studies that showed inconclusive results, both of which were conducted by the same team of researchers. (1,2)
A U.S. based study conducted in 1993 showed that a water extract of Ganoderma lucidum (Reishi) exhibited "significant anti-inflammatory activity." (4) Ten years later, an Indian research paper was published which stated that the use of Reishi extract helped decrease inflammation in acute edema by 56% and in chronic edema by 60%. (3) Using the "Article References" link on this page, you will find references to seven additional research articles that confirm Reishi extract as a powerful anti-inflammatory agent. (5,6,7,8,9,10,11)
Next we'll be looking at some studies that more directly relate to the use of Reishi extract with arthritis. A paper published in 2006 by Blum et al. claimed to provide supporting clinical evidence demonstrating that use of Reishi extract for joint health was both safe and effective. (12)
Also that same year, a Chinese study by Xi Bao et al. came to the conclusion that Reishi plus another medicinal herbal remedy commonly used in China seemed to have a "beneficial immunomodulatory effect" on arthritis. (13)
The answer as to how, precisely, Reishi extract accomplishes this "immunomodulatory effect" may have been given by another Chinese study the following year, which states that an isolated Reishi polysaccharide peptide "significantly inhibited" RASF, which is an indicator of rheumatoid arthritis. (RASF stands for "Rheumatoid Arthritis Synovial Fibroblasts.") (14)
Several additional papers have been published that summarize positive results in the use of Reishi against arthritis. (15,16,17) One even states that Reishi compares favorably to prednisone, albeit without side effects. (18) On the other hand, a separate study found that supplementing with Reishi helped balance the side effects of prednisolone* that were experienced by some patients, including protein in the urine and cell toxicity. (19) (Prednisolone is the active compound of prednisone, which gets broken down by the liver and converted to prednisolone.)
In conclusion, the majority of research on the use of Reishi extract for inflammation or arthritis appears to support its effectiveness. Please remember that it is very important to always consult a licensed medical doctor before using any herb for medicinal purposes.
Name clarification: The Japanese name Reishi includes many closely related species. By far the most prevalent is Ganoderma lucidum (Common Reishi or Red Reishi), a species rare in the U.S. but common in South East Asia. The English common name for Ganoderma lucidum is Varnished Conk. In China, its known as Ling Zhi.
Several closely related species of Ganoderma also go by the name of "Reishi". Most common of these are the Hemlock Reishi (Ganoderma tsugae) found on Hemlocks in the Appalachian Mountains, and the Chinese species "Black Reishi" (Ganoderma sinense). Less common are Ganoderma resinaceum (sometimes called "Red Reishi," although that name is more often used for G. lucidum), Ganoderma neo-japonicum (no common name other than "Reishi"), and Ganoderma japonicum (Purple Reishi).
About the Author:
Dr. Rafael works as a natural health researcher and author since the mid 90's, specializing in mycomedicinals. Click Extract of Reishi for quality products and free articles on medicinal mushrooms. Reishi and Arthritis Article References
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